Wet milling of pharmaceutical products is important for creating uniform particle size and enhancing drug product bioavailability to contemporary regimes. The advancement of manufacturing means that highly specialized bead mills and dispersion systems are in use to reduce active ingredients to nanoscale sizes, which allow for consistency in product quality, and product stability. Pharmaceutical wet milling technology can be applied under stricter conditions of use, which includes controlled temperature operations, contamination-free processing, and scalable for production.