What Sets Glioblastoma (GBM) Apart?
Glioblastoma (GBM) is classified as a grade IV astrocytoma. While rare, it is the most common and deadly malignant brain tumor in adults. Current treatment protocols include surgical resection, followed by radiation and chemotherapy with temozolomide, but the effectiveness is limited and long-term survival remains rare.
This has created an urgent demand for new therapies that target the tumor more precisely and effectively.
A New Wave in Treatment and Market Growth
The glioblastoma market by treatment is expanding with novel approaches like targeted therapies, tumor-treating fields, and immunomodulatory drugs. These innovations are helping to overcome drug resistance and improve patient outcomes.
As researchers uncover more about GBM’s molecular pathways, precision oncology is beginning to play a larger role, tailoring treatments to each patient’s tumor profile.
Paxalisib: Targeting the Tumor’s Inner Workings
A key therapy making waves is paxalisib, which inhibits the PI3K/Akt/mTOR signaling pathway commonly activated in GBM. Unlike many other drugs, paxalisib is formulated to cross the blood-brain barrier and target cancer cells directly. Its potential to extend survival in hard-to-treat patient subgroups makes it a compelling candidate in ongoing clinical trials.
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