Hot Flashes Market Set for Significant Growth | Major Players: Veru Healthcare, Fervent Pharmaceuticals, Ogeda, Bayer, L

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Market Drivers and Insights

Several critical aspects are accelerating the growth of the hot flashes market:

Rising prevalence of hot flashes across demographics, especially among menopausal and postmenopausal women.
An increasing number of emerging therapies under clinical development.
Strategic collaborations and partnerships among pharmaceutical companies to advance product pipelines.
Growing awareness and demand for non-hormonal treatment alternatives.

The comprehensive report highlights how various market drivers and challenges impact growth, providing a complete view of the hot flashes treatment ecosystem.

Key Players Fueling Innovation in Hot Flashes Treatments

A number of prominent pharmaceutical companies are at the forefront of developing innovative therapies to address hot flashes more effectively. These include:

Veru Healthcare
Fervent Pharmaceuticals
Ogeda
Bayer
Lundbeck A/S
TherapeuticsMD
MenoGeniX
Mitsubishi Tanabe Pharma
QUE Oncology
Pherin Pharmaceuticals

These companies are either advancing novel compounds or improving upon existing treatment regimens. The combined market size will reflect both the current therapies and those expected to launch during the forecast period within the seven major pharmaceutical markets (7MM).

According to DelveInsight, the market is poised to grow at a noteworthy compound annual growth rate (CAGR) over the next several years.

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Understanding Hot Flashes: A Medical Perspective

Hot flashes (HFs) are defined as sudden and intense sensations of heat, often accompanied by profuse sweating, flushing, chills, and a sense of internal warmth. These episodes are due to dysregulated thermoregulation, where minor elevations in core body temperature (Tc) can trigger an exaggerated heat-loss response, including peripheral vasodilation and sweating.

More than 80% of menopausal women experience hot flashes, making it one of the most common and disruptive symptoms during the climacteric phase. These episodes typically last between 1 to 5 minutes and can significantly affect quality of life, particularly when frequent or severe.

Several factors are linked to an increased incidence of hot flashes, including:

Obesity
African heritage
Lower socioeconomic status
Premenstrual syndrome (PMS)
Sedentary lifestyle
Smoking

In individuals suffering from hot flashes, the thermoneutral zone (the temperature range within which the body doesn’t need to sweat or shiver) is narrowed. As a result, even minor fluctuations in temperature can provoke strong vasodilatory responses, leading to intense heat sensations and sweating.

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Recent Clinical and Market Highlights

Recent developments have added momentum to hot flashes research:

In April, Fervent Pharmaceuticals launched a virtual Phase II clinical trial, known as the M2S Hot Flash Study, designed to evaluate the efficacy of its novel treatment targeting moderate to severe hot flashes, night sweats, and associated sleep disturbances in peri- and post-menopausal women.
In January 2020, Veru Inc. released interim results from its Phase II clinical trial of Zuclomiphene citrate, a nonsteroidal oral estrogen receptor agonist. This study, focusing on androgen deprivation therapy (ADT)-induced hot flashes in men with advanced prostate cancer, reported statistically significant reductions in hot flash frequency. Importantly, the treatment was well-tolerated, with no serious adverse events, including breast pain or enlargement or venous thromboembolism.

Epidemiology: Hot Flashes Patient Segmentation

The epidemiological insights provided by DelveInsight are based on a robust data model, offering a detailed overview of patient demographics and disease burden. The analysis includes both historical and projected patient populations, segmented into:

Overall Hot Flashes Prevalence
Age-specific Prevalence
Gender-specific Prevalence
Diagnosed and Treatable Populations

These statistics span the 2019–2032 timeframe across the 7MM (U.S., EU5, and Japan), providing a strong foundation for forecasting treatment needs and market opportunities.

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Hot Flashes Treatment Market: Trends and Forecast

This segment of the report offers a thorough evaluation of the current treatment landscape, including market trends, therapy impact, pricing strategies, and unmet clinical needs. It provides a granular analysis of both approved therapies and pipeline drugs, examining factors such as:

Annual cost of therapy
Mechanism of action
Compliance and adherence rates
Target patient populations
Competitive landscape
Expected launch dates
Brand perception
KOL (Key Opinion Leader) insights

Data are presented using detailed tables and charts to provide an at-a-glance understanding of market behavior. The market is projected to evolve dramatically through 2032 due to the introduction of first-in-class therapies and rising patient awareness.

Key Emerging Therapies for Hot Flashes

Fezolinetant (Astellas Pharma)
An investigational selective NK3 receptor antagonist, Fezolinetant is being evaluated as a non-hormonal treatment to reduce the severity and frequency of vasomotor symptoms (VMS) related to menopause. If approved, it would be a first-in-class therapy in its category.
Elinzanetant (Bayer)
A dual NK1/3 receptor antagonist, Elinzanetant targets hyperactive hypothalamic neurons (KNDy neurons) that are responsible for thermoregulatory dysfunction in menopausal women. The drug is being developed as a non-hormonal oral solution for hot flashes.
Fezolinetant (Ogeda)
Originally developed by Ogeda (a subsidiary of Astellas), this oral small molecule mimics the neuronal effects of estrogen. It not only regulates temperature but also has potential applications in PCOS, uterine fibroids, and endometriosis by modulating hormonal pathways in a non-castrating manner.
Zuclomiphene Citrate (Veru Inc.)
A nonsteroidal estrogen receptor agonist, this drug has shown efficacy in reducing moderate to severe hot flashes in men undergoing ADT for prostate cancer. Phase II studies indicate strong safety with no significant adverse events reported.